Hyaluronidase is an enzyme that plays an important role in the breakdown of hyaluronic acid (HA), a natural component of our connective tissues and skin. HA is commonly used in cosmetic procedures as a dermal filler to add volume and reduce the appearance of some wrinkles.

Hyaluronidase works by catalyzing the hydrolysis of the bonds within hyaluronic acid, breaking it down into smaller fragments. This enzymatic activity leads to the degradation and dissolution of the filler material. The breakdown of HA disrupts its structure and reduces its viscosity, allowing the body’s natural processes to remove it more effectively.

When hyaluronidase is injected into the area where HA filler is present, it spreads throughout the tissues and acts on the hyaluronic acid molecules. The enzyme cleaves the glycosidic bonds between the sugar subunits in the HA polymer, resulting in the breakdown of the filler substance.

It’s important to note that hyaluronidase is a non-specific enzyme, meaning it can break down other forms of hyaluronic acid present in the body, not just filler material.

Hyaluronidase serves as an effective solution for dissolving hyaluronic acid-based fillers when desired, allowing for adjustments or corrections in cosmetic procedures. However, its usage should be carefully considered.

Common reasons for needing filler dissolution include:

Treatment dissatisfaction: Sometimes, individuals may experience undesired aesthetic outcomes or asymmetry after receiving dermal fillers. This could be due to overcorrection, product migration, or improper placement.

Complications: In some cases, complications such as vascular compromise, tissue necrosis, or infection may occur following filler injections. It may be necessary to rapidly dissolve the filler and alleviate these complications.

Uneven filler distribution: Filler products may distribute unevenly within tissues, leading to asymmetry or irregularities. Filler dissolving can be used to address these issues by dissolving and redistributing the filler material.

Filler correction or adjustment: In some cases, client may desire adjustments or modifications to their filler treatment. Filler dissolving allows for the targeted dissolution of specific areas, allowing for the necessary adjustments to be made.

The time it takes to dissolve fillers can vary depending on several factors, including the type of filler used, its concentration of solution, the volume injected, and the individual’s metabolism. In general, the process of filler dissolution is relatively rapid, but complete resolution may take some time.

Typically, the effects of dissolving can be observed within hours to a few days after injection. The enzyme starts breaking down the hyaluronic acid (HA) filler by cleaving its glycosidic bonds. However, the exact timeframe for complete dissolution of the filler material can vary.

Small amounts of filler may dissolve completely in a shorter period, while larger volumes or more robustly cross-linked fillers may take longer to dissolve fully. It can take from a few days for the filler material to be completely metabolized and cleared from the body.

Individual response may vary, and close evaluation is necessary to ensure desired outcomes and to address any potential complications.

Dissolving treatment for filler dissolution is generally safe. However, there are potential side effects and risks that should be considered.

Allergic reactions: Although rare, some individuals may develop allergic reactions to the enzyme itself. Symptoms may include redness, swelling, itching, hives or in very rare cases anaphylaxis. Immediate medical attention should be sought if an allergic reaction occurs. We always conduct a patch test before, it isn’t optional.

Tissue damage: In rare cases, the injection of hyaluronidase may lead to tissue damage.

Dilution of endogenous hyaluronic acid: Hyaluronidase is a non-specific enzyme that can also break down endogenous hyaluronic acid (HA) in the body. While this effect is temporary, it can lead to transient loss of volume or moisture in treated areas.

It is important to disclose any known allergies or medical conditions to your injector before undergoing dissolving treatment. They will assess your suitability for the procedure and monitor your response closely to minimize potential risks. Additionally, post-treatment care instructions should be followed diligently to optimize outcomes and minimize side effects.

Hyaluronidase can break down hyaluronic acid (HA) fillers, which are the most commonly used dermal fillers in cosmetic procedures. HA fillers are made of cross-linked hyaluronic acid molecules.

Hyaluronidase is highly effective in dissolving and degrading HA fillers due to its enzymatic activity. It acts by cleaving the glycosidic bonds within the HA polymer, causing the breakdown of the filler material.

However, it’s important to note that the enzyme is not effective for dissolving other types of fillers that are not based on hyaluronic acid. Different dermal fillers may use various materials such as calcium hydroxylapatite, poly-L-lactic acid, or polymethylmethacrylate microspheres, which have different chemical structures and properties.

Since hyaluronidase specifically targets and catalyzes the hydrolysis of hyaluronic acid, it will not have the same effect on non-hyaluronic acid fillers. Non hyaluronic acid types of fillers require different approaches or procedures for removal or correction, or cannot be dissolved at all.

It can potentially be used to dissolve hyaluronic acid (HA) fillers placed in various parts of the face and body. Its effectiveness in different areas depends on several factors, mainly including the specific filler product used.

In general, it can be utilized to dissolve HA fillers in areas such as the cheeks, lips, nasolabial folds, chin, under-eye hollows, temple regions, and other facial regions where HA fillers are commonly injected. The enzyme acts on the hyaluronic acid molecules, breaking down the filler material.

The decision to use filler dissolving enzyme should be determined after a careful evaluation, considering factors such as the location of the filler, the anatomy of the area, and the client’s specific needs.

The number of sessions required for complete dissolution of hyaluronic acid (HA) fillers can vary depending on multiple factors. These include the specific filler used, its volume, and the individual’s unique response.

In some cases, a single session of filler dissolving treatment may be sufficient to achieve desired results, especially for smaller volumes or softer and medium fillers. The effects of filler dissolving treatment can often be observed instant or within hours after injection.

However, for larger volumes of filler or more robustly cross-linked fillers, couple of sessions of dissolving treatment may be required for complete dissolution. Additional treatment may be required a few days or weeks later, depending on the individual circumstances.

It’s essential to note that the timeline for complete dissolution can also vary among individuals. Metabolism and elimination rates can differ, affecting the duration it takes for the body to break down and clear the dissolved filler material.

To determine the specific treatment plan, it is best to consult with a professional.

The procedure of filler dissolution is usually well-tolerated and minimally uncomfortable. However, individual experiences may vary.

Dissolving enzyme is typically injected into the same or nearby area where the filler is present, some individuals may experience mild discomfort during the injection process. The sensation can range from a slight pinprick to a mild stinging or burning sensation. The discomfort is usually temporary and brief.

The decision to use numbing cream largely depends on the client’s preference and pain tolerance. A topical anesthetic cream may be applied before the procedure to help minimize any potential discomfort.

It is important to communicate any concerns or discomfort to your injector during the procedure. They can help manage any discomfort and ensure the procedure is as comfortable as possible.

The timeframe for seeing results after filler dissolving treatment can vary, depending on the individual and the specific circumstances. However, in many cases, the effects of enzyme treatment can be observed relatively quickly.

Following the injection of filler dissolving, some individuals may notice initial changes immediately or within a few hours. This can include a reduction in the volume or appearance of the treated area, as the enzyme starts breaking down the hyaluronic acid filler.

However, it’s important to note that the complete resolution of the filler material may take some time. Larger volumes or more robustly cross-linked fillers may require additional sessions or more extended periods to fully dissolve.

Individual metabolism, the nature of the filler can all influence the rate of filler breakdown. In general, it can take anywhere from a few minutes to a week for the filler material to be completely metabolized and eliminated from the body.

It’s important to have realistic expectations, as the timeline for results can vary. Close monitoring by a qualified professional is advised to assess progress and make any necessary adjustments or additional treatments, if needed.

There are several reasons why individuals may choose to get dermal fillers dissolved, and some specific reasons include:

Undesired or incorrect shape of lips after lip fillers: If the outcome of lip filler injections results in an undesired shape or aesthetic appearance of the lips, dissolving the filler can help restore a more natural or correct shape.

Asymmetrical lips or cheeks after filler injections: If the distribution of the filler material leads to asymmetry in the lips or cheeks, filler dissolving can help to adjust the filler to achieve better symmetry.

Too large lips after filler injections: In cases where the volume of the lips is overly increased or larger than desired, hyaluronidase treatment can reduce the volume and restore a more proportionate appearance.

Too much filler injected in cheeks: If excessive filler has been injected in the cheeks, resulting in an unnatural or overly augmented appearance, hyaluronidase can be used to dissolve the excess filler and restore a more balanced look.

Complications during dermal filler injections: In situations where complications such as vascular compromise occur during or after dermal filler injections, hyaluronidase may be necessary to rapidly dissolve the filler and mitigate the associated complications.

Lumps in lips after lip filler: Sometimes, the presence of lumps or irregularities in the lips after lip filler injections can be a source of dissatisfaction. Hyaluronidase can help break down the filler material and smooth out any lumps or bumps.

Filler migration outside the lip area: In cases where the injected filler material migrates and spreads beyond the desired treatment area, such as outside the lip borders, filler can be dissolved and correct the filler’s misplaced distribution.

Filler dissolving can help address the above concerns and provide options for adjustment or correction of unwanted outcomes associated with dermal filler treatments.

After dissolving lip filler, the results are typically visible almost instantly. The hyaluronidase works to break down the filler material, and the dissolved filler continues to break down fully over the next few days, usually within 24-48 hours. It is common to experience bruising and tenderness in the treated area after the dissolution procedure.

If you wish to have your lips augmented again with fillers, it is generally recommended to wait at least a month to allow your lips to fully recover from the dissolving treatment. This waiting period allows time for any bruising, tenderness, or swelling to subside, and for the tissues to heal.

During the recovery period, some individuals may choose to opt for skin boosters to help accelerate the healing and recovery process of the lips and the skin surrounding them. Skin boosters are a type of dermal filler specifically designed to improve the hydration and elasticity of the skin. However, the use of skin boosters during the recovery period is optional and can be discussed with your injecting professional.

After a period of about a month or two, when the lips have fully recovered, you can typically proceed with a new lip filler treatment to achieve the desired augmentation. It is important to consult with a trained professional who can assess your specific needs, provide personalized recommendations, and ensure safe and effective lip augmentation.